Doxorubicin-Loaded Silica Nanocomposites for Cancer Treatment
نویسندگان
چکیده
Silica nanoparticles (SiNPs) are a promising material for nanomedicine technology. SiNPs considered powerful tool drug delivery, functional coatings and films, biomolecule separation due to their stability, biocompatibility, accessible surface modification. Herein, the synthesis of nylon 6 (SiNPs-Nylon) coated nanocomposites was proposed. Transmission electron microscopy (TEM) dynamic light scattering (DLS) were used morphology, size, stability analysis. Anticancer doxorubicin (DOX) loading pH-dependent release experiments presented. DOX-loaded with high capacities up 258 μg/mg (DOX/SiNPs) 493 (DOX/SiNPs-Nylon) show effective inhibition A549 HEK 293FT cell lines. The IC50 values 0.08 ± 0.01 µM in terms DOX amount recalculated as 0.31 0.04 µg/mL concentration cells. Therefore, silica have potential cancer treatment.
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ژورنال
عنوان ژورنال: Coatings
سال: 2023
ISSN: ['2079-6412']
DOI: https://doi.org/10.3390/coatings13020324